In vitro studies of BMY-28142, a new broad-spectrum cephalosporin.
نویسندگان
چکیده
BMY-28142 was compared with other broad-spectrum antibiotics against gram-positive cocci and gram-negative bacilli. BMY-28142 was highly active against all gram-negative bacilli and especially against Enterobacter cloacae, Serratia marcescens, and Morganella morganii. Its in vitro activity suggests that BMY-28142 should prove to be useful for the treatment of gram-negative bacillary infections.
منابع مشابه
Affinity of cephalosporins for beta-lactamases as a factor in antibacterial efficacy.
Strains of Escherichia coli, Enterobacter aerogenes, and Enterobacter cloacae that were resistant to ceftazidime (MIC greater than 16 micrograms/ml) but susceptible to BMY 28142 (MIC less than 4 micrograms/ml) were found to contain higher levels of beta-lactamase activity (50- to 3,340-fold) than control strains of the corresponding species. Ceftazidime was at least as resistant as BMY 28142 to...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 27 2 شماره
صفحات -
تاریخ انتشار 1985